Neural Circuitry Underlying the Central Hypertensive Action of 1 Nesfatin-1: Melanocortins, Corticotropin Releasing Hormone
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چکیده
1 NESFATIN-1: MELANOCORTINS, CORTICOTROPIN RELEASING HORMONE AND 2 OXYTOCIN 3 4 5 6 Gina L. C. Yosten and Willis K. Samson 7 8 Department of Pharmacological and Physiological Science 9 Saint Louis University School of Medicine 10 Saint Louis, Missouri 11 12 13 14 Running Title: Neural Circuitry of Nesfatin-1 15 16 17 18 19 20 Corresponding Author: 21 22 Gina L. C. Yosten, Ph.D. 23 24 Department of Pharmacological and Physiological Science 25 Saint Louis University School of Medicine 26 1402 S. Grand Blvd 27 Saint Louis, MO 63104 28 Phone: 314-977-6354 29 Fax: 314-977-8670 30 Email: [email protected] 31 32 33 34 35 36 37 38 39 40 41 42 43 Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, 44 corticotropin releasing hormone and oxytocin. 45 46 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (March 5, 2014). doi:10.1152/ajpregu.00396.2013
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Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin.
Nesfatin-1 is produced in the periphery and in the brain where it has been demonstrated to regulate appetite, stress hormone secretion, and cardiovascular function. The anorexigenic action of central nesfatin-1 requires recruitment of neurons producing the melanocortins and centrally projecting oxytocin (OT) and corticotropin-releasing hormone (CRH) neurons. We previously have shown that two co...
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